Dr. T. O. OladosuSOLANKE, Olajumoke Temitope2026-08-272026-08-272019-03-27https://ir.bellsuniversity.edu.ng/handle/123456789/513xi,51pages,illustration;.hardbackUrinary Tract Infections (UTIs) emanate from the invasion of urinary tract by pathogens, these conditions are most commonly encountered in women. UTI could be categorised into acute, recurrent or complicated. Treatment of UTI with conventional antibiotics had been the mainstay of managing UTI in the past. However, due to increasing antibiotic resistance, therapy by antibioties has become less effective. Urine samples were cultured for isolation of bacterial pathogens, these isolates were characterised by culturomic methods. Antibiogram profiling of isolates was conducted using antibiotics to detect antimicrobial resistance levels of isolates. Plasmid and Chromosomal profiling was conducted on Multi-drug resistant isolates to detect the presence of the resistance genes. Ethanolic extracts of Corchorus olitorius and Xylopia aethiopica were obtained by Hot continuous extraction using the Soxhlet apparatus. Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa were the multidrug resistant isolates form this study. The floroquinolones resistant genes were detected in the plasmids of the MDR isolates, detected by the use of primers gyr A and aac. The crude plants extracts of Xylopia aethiopica and Corchorus olitorius have better in vitro antimicrobial activity against the MDR bacteria obtained from this study. Combination of the two crude plants extracts had lower antimicrobial effect against the multidrug resistant pathogens. Corchorus olitorius displayed a higher level of antimicrobial activity, hence it could exploited for nutraceutical properties in individuals with urinary tract infections.enAttribution 4.0 InternationalTreatmentUrineDissertation